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Leydig Cell cover
The Leydig Cell

edited by Anita Payne, Matthew Hardy and Lonnie Russell

This volume presents an up-to-date compilation of information on the development, structure and function of the cell that produces testosterone. The Leydig Cell is invaluable for serious researchers and students of male reproductive physiology. Topics covered range from the identification of the cell by Franz Leydig in 1850 to current efforts targeting the Leydig cell as a means of achieving male contraception.

The Leydig Cell features:
33 chapters written by recognized experts
Hundreds of tables, figures and illustrations
History of early research on the Leydig cell
Over 800 pages - 8.5" x 11" - on glossy paper
Hardback with color cover
Color section
Foreword by David M. de Kretser
Bibliography of 4,000 references
Published in 1996

800+ pages - ISBN 0-962742-27-9 - $137.50

Table of Contents:

Foreword by David M. de Kretser
Preface by A. H. Payne, M. P. Hardy and L. D. Russell

Historical Introduction

1.
A history of Studies on Testicular Leydig Cells: The First Century
1-30
A.K. Christensen
2.
Androgens: Early Attempts to Evaluate Leydig Cell Function in Man
31-42
C. W. Bardin


Structure and Development

3.
Mammalian Leydig Cell Structure
43-96
I. D. Russell
4.
Comparative Cytology of the Leydig Cell
97-142
J. Pudney
5.
The Cell Biology and Function of the Fetal Leydig Cell
143-158
L. J. Pelliniemi, T. Kuopio and K. Fröjdman
6.
Pubertal Development of Leydig Cells
159-174
R.-S. Ge, L.-X. Shan and M. P. Hardy
7.
Leydig Cell Development in Humans
175-202
H. E. Chemes
8.
Regeneration of Leydig Cells After Depletion by EDS: A Model for Postnatal Leydig Cell Renewal
203-220
K. J. Teerds
9.
Leydig Cell Structure and Function During Aging
221-230
H. Chen, L. Luo and B. R. Zirkin


Steroidogenesis

10.
Regulation of Leydig Cell Cholesterol Transport
231-240
D. A. Freeman and F. F. G. Rommerts
11.
Acute Regulation of Leydig Cell Steroidogenesis
241-258
D. M. Stocco
12.

Structure, Function and Regualtion of Steroidgenic Enzymes in the Leydig Cell

259-286
A. H. Payne and P. J. O'Shaughnessy
13.
Metabolism of Testosterone in Leydig Cells and Peripheral Tissues
287-306
K. Sundaram and N. Kumar
14.
Endocrinology of Leydig Cells in Nonmammalian Vertebrates
307-332
G. B. Callard

Regulation by Luteinizing Hormone

15.
The Luteinizing Hormone Receptor
333-350
M. L. Dufau
16.
Transduction of the Luteinizing Hormone Signal Within the Leydig Cell
351-364
B. A. Cooke
17.
Ontogeny of the Luteinizing Hormone Action in the Male
365-382
I. Huhtaniemi

Regulation By Factors Other Than Luteinizing Hormone

18.
Regulation of Leydig Cell Functions by Hormones and Growth Factors Other Than LH and IGF-1
383-406
J. M. Saez and H. Lejeune
19.
Leydig Cell Regulation by Catecholamines and Neuroendocrine Messengers
407-418
A. Mayerhofer

Color Section

20.
Leydig Cell Structure and Function in Seasonal Breeders
431-450
A. Bartke, A. P. Sinha Hikim and L. D. Russell
21.
Leydig Cell-Macrophage Interactions: An Overview
451-466
D. B. Hales
22.
Leydig Cell-Sertoli Cell Interaction
467-476
S. R. Sylvester
23.
Insulin-Like Growth Factor-I Regualtion of the Leydig Cell
477-492
T. Lin
24.
Regulation of Leydig Cells by Inhibins and Activins
493-506
G. P. Risbridger

Physiological, Pathological and Clinical Aspects of Leydig Cells

25.
Fluid Exchange and Transport of Endocrine and Paracrine Solutes Supporting the Leydig Cell
507-522
C. Desjardins
26.
Immortalized Leydig Cell Lines as Models for Studying Leydig Cell Physiology
523-534
S. R. Hoelscher and M. Ascoli
27.
Leydig Cell Responsiveness to Hormonal and Nonhormonal Factors In Vivo and In Vitro
535-554
G. R. Klinefelter and W. R. Kelce
28.
Leydig Cell Neoplasia
555-572
R. A. Huseby
29.
Leydig Cell Toxicology
573-596
I. D. Morris
30.
Pharmacologic Influence on Angrogen Biosynthesis
597-628
V. Papadopoulos
31.
The Leydig Cell as a Target for Male Contraception
629-662
G. F. Weinbauer and E. Nieschlag
32.
Clinical Evaluation of Leydig Cell Function
663-694
R. S. Swerdloff and C. Wang
33.
Involvement of Leydig Cell Function in Precocious Puberty
695-702
J. Z. Kasa-Vubu
34.
Conditions Affecting Leydig Cells
703-734
S. M. L. C. Mendis-Handagama

Appendices I. Bibliographic Information

 

800+ pages - ISBN 0-962742-27-9 - $137.50

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