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Pathology of the Mouse
Pathology of the Mouse
edited by: Robert Maronpot
associate editors: Gary Boorman & Beth Gaul

The mouse is an up-and-coming research animal and is heavily utilized in toxicological testing. The mouse is the least costly of the rodents and the relative ease with which transgenic research can be conducted makes it a desirable animal model. An outstanding team of pathologists, headed by Dr. Robert Maronpot at the National Institute of Environmental Heath Sciences, provides a comprehensive survey of mouse pathology. This book is both a reference and atlas in that it covers all systems of the body and is heavily illustrated. Pathology of the Mouse is an indispensable reference for pathologists and biomedical scientists. Each pathologist should have a copy within arm's reach!


Pathology of the Mouse features:

  • Comprehensive and authoritative
  • 26 peer reviewed chapters
  • Over 1000 illustrations
  • Glossy paper
  • Over 700 pages
  • Hard-bound
  • Mechanistically oriented
  • Published in 1999


700+ pages - ISBN 1-889899-02-X - $199.50

Table of Contents

Editorial Board
viii
Contributors
ix
Preface
xi
Acknowledgements
xi
1
History of the B6C3F1 Mouse - Ghanta N. Rao & Gary A. Boorman
1
Introduction
1
History of the Parental Strains
1
Characteristics of B6C3F1 Hybrid and its Parental Strains
3
Justification for the Use of the B6C3F1 Hybrid in Chemical Carcinogenicity Studies
4
Carcinogen Susceptibility of the B6C3F1 Hybrid Mouse
5
2.
Growth, Body Weight Patterns and Life Span of the B6C3F1 Mouse - Ghanta N. Rao
7
Introduction
7
Animals, Husbandry, and Observations
7
Growth and Body Weight Patterns
8
Mortality Patterns
9
Discussion
10
Acknowledgements
11
3.
The Teeth - Philip H. Long & Joel R Leininger
13
Introduction
13
Normal Teeth
13
Congenital Lesions
17
Degenerative Lesions
17
Inflammatory and Vascular Lesions
19
Hyperplastic and Neoplastic Lesions
20
Miscellaneous Lesions
25
Toxicologic Lesions
27
Acknowledgments
27
4.
Oral Cavity, Esophagus and Stomach - Joel R. Leininger, Micheal P. Jokinen, Charles A. Dangler & Laurence O. Whiteley
29
Introduction
29
Normal Upper Digestive Tract
29
Congenital Lesions
33
Degenerative Lesions
34
Inflammatory and Vascular Lesions
36
Hyperplastic and Neoplastic Lesions
38
Miscellaneous Lesions
45
Toxicologic Lesions
45
5.
Salivary, Harderian and Lacrimal Glands - Suzanne Botts, MMicheal Jokinen, Elias T. Gaillard, Micheal R. Elwell & Peter C. Mann
49
Introduction
49
Normal Salivary Glands
49
Congenital Lesions of the Salivary Glands
54
Degenerative Lesions of the Salivary Glands
54
Inflammatory and Vascular Lesions of the Salivary Glands
55
Hyperplastic and Neoplastic Lesions of the Salivary Glands
56
Toxicologic Lesions of the Salivary Glands
62
Normal Harderian Gland
62
Degenerative Lesions of the Harderian Gland
63
Inflammatory Lesions of the Harderian Gland
63
Hyperplastic and Neoplastic Lesions of the Harderian Gland
63
Toxicologic Lesions of the Harderian Gland
70
Mechanistic Studies of the Harderian Gland
71
Normal Lacrimal Glands
71
Degenerative Lesions of the Lacrimal Glands
73
Congenital Lesions of the Lacrimal Glands
73
Inflammatory Lesions of the Lacrimal Glands
74
Hyperplastic and Neoplastic Lesions of the Lacrimal Glands
74
Toxicologic lesions of the Lacrimal Glands
77
6.
Small and Large Intestine, and Mesentery - Cynthia C. Shackelford & Michael R. Elwell
81
Introduction
81
Normal Intestine
81
Congenital Lesions
89
Degenerative Lesions
90
Inflammatory and Vascular Lesions
93
Hyperplastic and Neoplastic Lesions
99
Miscellaneous Lesions
111
Toxicologic Lesions
112
7.
Liver and Gallbladder - T. Harada, A. Enomoto, G. A. Boorman & R. R. Maronpot
119
Introduction
119
Normal Liver and Gallbladder
120
Congenital Lesions
126
Degenerative Lesions
126
Inflammatory and Vascular Lesions
137
Hyperplastic and Neoplastic Lesions
140
Miscellaneous Non-neoplastic Liver and Gallbladder Lesions
163
Toxicologic Lesions
167
Mechanistic Studies with the Liver
171
8.
Exocrine and Endocrine Pancreas - Gary A. Boorman & Robert C. Sills
185
Introduction
185
Normal Exocrine and Endocrine Pancreas
185
Congenital Lesions
190
Degenerative Lesions
190
Inflammatory and Vascular Lesions
193
Hyperplastic and Neoplastic Lesions
194
Miscellaneous Lesions
201
Toxicological Lesions
202
9.
Kidney - John Curtis Seely
207
Introduction
207
Normal Kidney
207
Congenital Lesions
211
Degenerative Lesions
212
Inflammatory and Vascular Lesions
215
Hyperplastic and Neoplastic Lesions
217
Toxicologic Lesions
226
10.
Ureter, Urinary Bladder, and Urethra - Elias T. Gaillard
235
Introduction
235
Normal Urinary Pathway
235
Congenital Lesions
241
Inflammatory and Vascular Lesions
241
Hyperplastic and Neoplastic Lesions
241
Miscellaneous Lesions
251
Toxicologic Lesions
254
11.

Nose, Larynx, and Trachea - Ronald A. Herbert & Joel R. Leininger

259
Introduction
259
Embryology
259
Normal Upper Respiratory Tract
260
Physiology
273
Congenital Lesions
274
Inflammatory and Vascular Lesions
274
Degenerative and Regenerative Lesions
275
Hyperplastic and Neoplastic Lesions
281
Miscellaneous Lesions
288
Toxicologic Lesions
289
12.
Lungs, Pleura, and Mediastinum - Darlene Dixon, Ronald A. Herbert, Robert C. Sills & Gary A. Boorman
293
Introduction
293
Normal Lung, Pleura, and Mediastinum
294
Congenital Lesions - Lung
300
Inflammatory and Vascular Lesions - Lung
300
Hyperplastic Lesions
302
Neoplastic Lesions
305
Miscellaneous Lesions
318
Toxicologic Lesions
320
Molecular Biology of Lung Tumors in Mice
323
13.
Thymus, Spleen, and Lymph Nodes - Jerrold M. Ward, Peter C. Mann, Hideki Morishima & Charles H. Frith
333
Thymus
Normal Thymus
333
Congenital Lesions
334
Disturbances of Growth
335
Degenerative Lesions
335
Inflammatory and Vascular Lesions
336
Hyperplastic Lesions
336
Neoplastic Lesions
337
Toxicologic Lesions
337
Spleen
Normal Spleen
339
Congenital Lesions
340
Degenerative Lesions
340
Inflammatory and Vascular Lesions
342
Hyperplastic Lesions
342
Neoplastic Lesions
344
Toxicologic Lesions
352
Lymph Nodes
Normal Lymph Nodes
354
Congenital Lesions
354
Degenerative Lesions
354
Inflammatory and Vascular Lesions
356
Hyperplastic Lesions
356
Neoplastic Lesions
357
Toxicologic Lesions
357
14.
Heart, Blood and Lymphatic Vessels - Michael R. Elwell & Joel F. Mahler
361
Introduction
361
Normal Heart and Vasculature
361
Congenital Lesions
364
Degenerative Lesions
364
Inflammatory Lesions
370
Hyperplastic and Neoplastic Lesions
372
Toxicologic Lesions
375
15.
The Male Reproductive Tract - Ann Radovsky, Kunitoshi Mitsumori & Robert C. Chapin
381
Introduction
381

Embryology

381
Anatomy, Histology and Physiology
382
Congenital Lesions
389
Degenerative Lesions
391
Inflammatory and Vascular Lesions
393
Hyperplastic and Neoplastic Lesions
394
Toxicologic Techniques and Lesions
401
Transgenic Models
405
16.
Ovary, Oviduct, Uterus, Cervix and Vagina - Barbara J. Davis, Darlene Dixon & Ronald A. Herbert
409
Introduction
409
Ovary
409
Oviduct
430
Uterus
431
Cervix and Vagina
440
17.
The Nervous System - Ann Radovsky & Joel F. Mahler
445
Introduction
445
Techniques
445
Embryology
448
Anatomy and Histology
449
Histopathology of the Nervous System
452
Developmental Lesions
453
Degenerative and Aging Lesions
454
Inflammatory and Vascular Lesions
456
Neoplasms
457
Toxicologic Lesions
465
Mechanistic Studies
468
18.
The Eyes - Volker Geiss & Katsuhiko Yoshitomi
471
Introduction
471
Normal
471
Congenital Lesions
475
Degenerative and Dystrophic Lesions
476
Inflammatory and Vascular Lesions
480
Hyperplastic and Neoplastic Lesions
482
Miscellaneous Lesions
485
Toxicological Lesions
485
19.
The Pituitary Gland - Joel F. Mahler & Michael R. Elwell
491
Introduction
491
Normal Pituitary Gland
491
Congenital Lesions
495
Degenerative Lesions
495
Inflammatory and Vascular Lesions
496
Proliferative Lesions
497
Miscellaneous Lesions
503
Toxicologic Lesions
504
Mechanistic Studies of Pituitary Tumorigenesis in Mice
505
20.
The Adrenal Gland - Abraham Nyska & Robert R. Maronpot
509
Introduction
509
Normal Adrenal Gland
509
Congenital Lesions
513
Degenerative Lesions
514
Inflammatory and Vascular Lesions
516
Hyperplastic, Hypertrophic, and Neoplastic Lesions
517
Neoplasms Metastatic to the the Adrenal
528
Experimental and Toxicologic Lesions
529
Mechanistic Studies with the Adrenal Glands
532
21.
The Thyroid and Parathyroid Glands - Jerry F. Hardisty & Gary A. Boorman
537
Introduction
537
Normal Thyroid and Parathyroid Gland
537
Congenital Lesions
543
Degenerative Lesions
545
Inflammatory and Vascular Lesions
545
Hyperplastic and Neoplastic Lesions
546
Miscellaneous Lesions
552
Toxicologic Lesions
552
22.
Skin and Subcutis - John C. Peckham & Katharina Heider
555
Introduction
555
Normal Skin and Subcutis
556
Congenital Lesions
562
Degenerative Lesions
562
Inflammatory and Vascular Lesions
565
Hyperplasia and Neoplastic Lesions
569
Miscellaneous Lesions
604
Toxicologic and Experimental Lesions
604
23.
Mammary Gland and Specialized Sebaceous Glands (Zymbal, Preputial, Clitoral, Anal) - John Curtis Seely & Gary A. Boorman
613
Introduction
613
Normal Development and Anatomy Mammary Gland
613
Congenital Lesions - Mammary Gland
615
Degenerative Lesions - Mammary Gland
615
Inflammatory and Vascular Lesions - Mammary Gland
615
Hyperplastic and Neoplastic Lesions - Mammary Gland
616
Toxicologic Lesions - Mammary Gland
623
Normal Development and Anatomy - Specialized Sebaceous Gland
623
Congenital Lesions - Specialized Sebaceous Gland
625
Degenerative Lesions - Specialized Sebaceous Gland
626
Inflammatory and Vascular Lesions - Specialized Sebaceous Gland
628
Hyperplastic and Neoplastic Lesions - Specialized Sebaceous Gland
628
Toxicologic Lesions - Specialized Sebaceous Gland
632
24.

Skeletal Muscle - Joel R. Leininger

637
Introduction
637
Normal Skeletal Muscle
637
Congenital Lesions
638
Degenerative Lesions
639
Inflammatory and Vascular Lesions
639
Hyperplastic and Neoplastic Lesions
640
Miscellaneous Lesions
641
Toxicologic Lesions
642
25.
Bones, Joints, and Synovia - Philip H. Long & Joel R. Leininger
645
Introduction
645
Normal Bones, Joints, and Synovia
645
Congenital Lesions
652
Degenerative Lesions
652
Inflammatory and Vascular Lesions
659
Hyperplastic and Neoplastic Lesions
662
Miscellaneous Lesions
672
Toxicologic Lesions
673
26.
Neoplasm Incidences in B6C3F1 Mice: NTP Historical Data - Joseph K. Haseman, Michael R. Elwell & James R. Hailey
679
Index
691
 

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